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Literature summary for 3.4.24.34 extracted from

  • Tester, A.M.; Cox, J.H.; Connor, A.R.; Starr, A.E.; Dean, R.A.; Puente, X.S.; Lopez-Otin, C.; Overall, C.M.
    LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity (2007), PLoS ONE, 2, e312.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.34

Protein Variants

Protein Variants Comment Organism
additional information polymorphonuclear cell infiltration towards lipopolysaccharides is abrogated in MMP-8-null mice Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
MMP-8 hemopexin C-domain recombinantly expressed, in excess inhibits the processing of LIX cytokine by blocking the binding site, overview Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
65000
-
 x * 85000, Pro-MMP-8, x * 65000, active mature MMP-8 Mus musculus
85000
-
 x * 85000, Pro-MMP-8, x * 65000, active mature MMP-8 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
epithelial cell-derived neutrophil activating peptide-78 + H2O Mus musculus i.e. ENA-78, or CXCL5, a cytokine ?
-
 ?
interleukin-8 + H2O Mus musculus
-
 ?
-
 ?
LIX + H2O Mus musculus a murine ELR+ CXC chemokine ?
-
 ?
additional information Mus musculus lipopolysaccharide responsiveness and neutrophil chemotaxis in vivo require polymorphonuclear MMP-8 activity, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the pro-MMP-8 is processed to its active form Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
intestine lipopolysacchride-treated Mus musculus
-
leukocyte
-
 Mus musculus
-
polymorphonuclear cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
epithelial cell-derived neutrophil activating peptide-78 + H2O i.e. ENA-78, or CXCL5, a cytokine Mus musculus ?
-
 ?
interleukin-8 + H2O
-
 Mus musculus ?
-
 ?
LIX + H2O a murine ELR+ CXC chemokine Mus musculus ?
-
 ?
LIX + H2O a murine ELR+ CXC chemokine, MMP-8 cleaves the 92-amino acid peptide LIX between Ser-Val at position 4-5 to generate a NH2-terminus at Val5 designated LIX (5-92), the binding site is located on the MMP-8 hemopexin C-domain Mus musculus ?
-
 ?
additional information lipopolysaccharide responsiveness and neutrophil chemotaxis in vivo require polymorphonuclear MMP-8 activity, overview Mus musculus ?
-
 ?
additional information no activity with the murine ELR+ CXC chemokines KC, MIP-2, and DCIP-1 Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 85000, Pro-MMP-8, x * 65000, active mature MMP-8 Mus musculus

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase-8
-
 Mus musculus
MMP-8
-
 Mus musculus
polymorphonuclear leukocyte collagenase
-
 Mus musculus