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Literature summary for 3.4.24.34 extracted from

  • Gutierrez-Fernandez, A.; Inada, M.; Balbin, M.; Fueyo, A.; Pitiot, A.S.; Astudillo, A.; Hirose, K.; Hirata, M.; Shapiro, S.D.; Noel, A.; Werb, Z.; Krane, S.M.; Lopez-Otin, C.; Puente, X.S.
    Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8) (2007), FASEB J., 21, 2580-2591.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information MMP8-/- mice, of a mixed C57BL/6J/129 background, deficient in collagenase-2/MMP-8 are more susceptible to develop skin cancer compared to wild-type mice, mutant mice show a significant delay in wound closure and an altered inflammatory response in their wounds, with a delay of neutrophil infiltration during the first days and a persistent inflammation at later time points, alterations in the TGF-beta1 signaling pathway and by an apoptosis defect in MMP8-/- mice, phenotype, overview Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6J mice
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Mus musculus C57/BL6J
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 C57BL/6J mice
-

Source Tissue

Source Tissue Comment Organism Textmining
skin
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
collagenase-2
-
 Mus musculus
MMP-8
-
 Mus musculus