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Literature summary for 3.4.24.3 extracted from

  • Peng, D.; Lin, J.; Huang, Q.; Zheng, W.; Liu, G.; Zheng, J.; Zhu, L.; Sun, M.
    A novel metalloproteinase virulence factor is involved in Bacillus thuringiensis pathogenesis in nematodes and insects (2016), Environ. Microbiol., 18, 846-862 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Bacillus thuringiensis
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Bacillus thuringiensis YBT-1518
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Synonyms

Synonyms Comment Organism
metalloproteinase ColB
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Bacillus thuringiensis

Expression

Organism Comment Expression
Bacillus thuringiensis colB exhibits a relatively stable low level expression. In the host condition, the expression of colB is continuously increased from the exponential phase to the later stationary phase. During the midexponential and stationary phases, colB exhibits significantly higher transcription levels in the host than in the LB condition, increasing by 121.5fold and 458.9fold respectively. Together, the expression and transcription analyses confirms that high levels of colB expression are induced in Bacillus thuringiensis in the intestine of infected Caenorhabditis elegans up
Bacillus thuringiensis ColB expression is highly induced and regulated by the global activator PlcR up

General Information

General Information Comment Organism
physiological function ColB is an important virulence factor required for Bacillis thuringiensis infecting Caenorhabditis elegans. The enzyme highly important for destruction of the intestine thereby facilitates the adaptation and colonization of Bacillus thuringiensis in Caenorhabditis elegans Bacillus thuringiensis