Literature summary for 3.4.24.3 extracted from

Eckhard, U.; Schoenauer, E.; Brandstetter, H.
Structural basis for activity regulation and substrate preference of clostridial collagenases G, H, and T (2013), J. Biol. Chem., 288, 20184-20194.

Search for more literature for 3.4.24.3

Cloned(Commentary)

Cloned (Comment)	Organism
-	Hathewaya histolytica
-	Clostridium tetani

Crystallization (Commentary)

Crystallization (Comment)	Organism
crystal structures of the collagenase unit of ColG in the presence and absence of the peptidic inhibitor isoamylphosphonyl-Gly-Pro-Ala bound to the active site. Comparison of isoforms ColH, ColT and ColG reveals differences in domain breathing motions and regulatory elements. Calcium and zinc are required for full peptidolytic activity	Hathewaya histolytica
crystal structures of the peptidase domains of ColH in the presence and absence of the peptidic inhibitor isoamylphosphonyl-Gly-Pro-Ala bound to the active site. In the unliganded ColH structure, the quaternary subdomain dynamics is modulated by an aspartate switch motion that binds to the catalytic zinc. One calcium binding site is in proximity to the catalytic zinc. Both ions are required for full activity. Loops close to the active site serve as characteristic substrate selectivity filter. Comparison of isoforms ColH, ColT and ColG reveals differences in domain breathing motions and regulatory elements. Calcium and zinc are required for full peptidolytic activity	Hathewaya histolytica
crystal structures of the peptidase domains of ColT in the presence and absence of the peptidic inhibitor isoamylphosphonyl-Gly-Pro-Ala bound to the active site. Comparison of isoforms ColH, ColT and ColG reveals differences in domain breathing motions and regulatory elements. Calcium and zinc are required for full peptidolytic activity	Clostridium tetani

Organism

Organism	UniProt	Comment	Textmining
Clostridium tetani	Q899Y1	isoform ColT	-
Clostridium tetani E88	Q899Y1	isoform ColT	-
Hathewaya histolytica	Q46085	isoform ColH	-
Hathewaya histolytica	Q9X721	isoform ColG	-

Synonyms

Synonyms	Comment	Organism
ColT	-	Clostridium tetani

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)