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Literature summary for 3.4.24.27 extracted from

  • Takeuchi, T.; Bottcher, A.; Quezada, C.M.; Meade, T.J.; Gray, H.B.
    Inhibition of thermolysin and human alpha-thrombin by cobalt(III) Schiff base complexes (1999), Bioorg. Med. Chem., 7, 815-819.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
recrystallized 3 times from DMSO Bacillus thermoproteolyticus

Inhibitors

Inhibitors Comment Organism Structure
phosphoramidon strong competitive inhibitor Bacillus thermoproteolyticus
[Co(acacen)(NH3)2]Cl irreversible inhibition Bacillus thermoproteolyticus

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc-containing neutral metalloendoprotease Bacillus thermoproteolyticus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34600
-
gel filtration Bacillus thermoproteolyticus

Organism

Organism UniProt Comment Textmining
Bacillus thermoproteolyticus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Bacillus thermoproteolyticus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000032
-
phosphoramidon pH 7.2, 25°C Bacillus thermoproteolyticus