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Literature summary for 3.4.24.26 extracted from

  • Beaufort, N.; Corvazier, E.; Hervieu, A.; Choqueux, C.; Dussiot, M.; Louedec, L.; Cady, A.; de Bentzmann, S.; Michel, J.B.; Pidard, D.
    The thermolysin-like metalloproteinase and virulence factor LasB from pathogenic Pseudomonas aeruginosa induces anoikis of human vascular cells (2011), Cell. Microbiol., 13, 1149-1167.
    View publication on PubMed
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Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Pseudomonas aeruginosa
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information metalloprotease Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Fibronectin + H2O Pseudomonas aeruginosa
-
 ?
-
 ?
Vitronectin + H2O Pseudomonas aeruginosa
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
 gene lasB
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Fibronectin + H2O
-
 Pseudomonas aeruginosa ?
-
 ?
Vitronectin + H2O
-
 Pseudomonas aeruginosa ?
-
 ?

Synonyms

Synonyms Comment Organism
LasB
-
 Pseudomonas aeruginosa

General Information

General Information Comment Organism
malfunction the exosecretome of the LasB-deficient pseudomonal strain PAO1lasBDELTA has limited impact on human vascular cell adherence and viability Pseudomonas aeruginosa
physiological function Pseudomonal LasB cleaves extracellular matrix proteins involved in adherence of vascular stromal cells in human host. LasB can induce vascular cell anoikis in human cells through simultaneous proteolysis of extracellular matrix components and cell receptors, suggesting the uPAR-vitronectin axis as a major target in this process. In heart valves of patients occurs extensive, LasB-dependent degradation of extracellular matrix-associated fibronectin and vitronectin, that preceeds cell de-adherence, whereas type I collagen shows limited degradation. Disruption of cell/ECM interactions resulting from uncontrolled pericellular proteolysis leads to detachment-induced cell apoptosis, anoikis, contributing to the morbid evolution of inflammatory vascular diseases, overview Pseudomonas aeruginosa