Literature summary for 3.4.24.26 extracted from

Azghani, A.O.; Baker, J.W.; Shetty, S.; Miller, E.J.; Bhat, G.J.
Pseudomonas aeruginosa elastase stimulates ERK signaling pathway and enhances IL-8 production by alveolar epithelial cells in culture (2002), Inflamm. Res., 51, 506-510.

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Application

Application	Comment	Organism
medicine	Inflammation and consequent lung dysfunction are hallmarks of recurrent Pseudomonas aeruginosa infections in cystic fibrosis lungs. The continued presence of bacterial components, including PE, can evoke an ongoing host inflammatory response by induction of inflammatory cytokinines and chemokinines such as interleukin-8. Although this cytokinine is essential for an effective host defense, continuous neutrophil transmigration and degranulation will damage the lung tissue through neutrophil-derived proteases. Therefore, the use of specific antibody against Pseudomonas elastase as adjuvant therapy along with antibacterial agents can prove an effective approach in the treatment of chronic Pseudomonas aeruginosa infection.	Pseudomonas aeruginosa

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	P14756	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
PE	-	Pseudomonas aeruginosa
Pseudomonas aeruginosa elastase	-	Pseudomonas aeruginosa

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Release 2023.1 (January 2023)