Application | Comment | Organism |
---|---|---|
medicine | enzyme can silence the function of proteinase-activated receptor-2 in the respiratory tract, thereby altering the host innate defense mechanisms and respiratory functions, and thus contributing to the setting of a disease like cystic fibrosis | Pseudomonas aeruginosa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
phosphoramidon | N-(alpha-rhamnopyranosyloxyhydroxyphosphinyl)-Leu-Trp | Pseudomonas aeruginosa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
PAR2 + H2O | Pseudomonas aeruginosa | - |
? | i.e. proteinase-activated receptor 2, enzyme cleaves the N-terminal domain of PAR2 from the cell surface without triggering receptor endocytosis as trypsin does. Cleavage does not activate PAR2, but disarms the recptor for subsequent activation by trypsin | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | - |
- |
- |
Pseudomonas aeruginosa | P14756 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Pseudomonas aeruginosa |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
elastin-Congo red | - |
Pseudomonas aeruginosa | ? | - |
? | |
PAR2 + H2O | - |
Pseudomonas aeruginosa | ? | i.e. proteinase-activated receptor 2, enzyme cleaves the N-terminal domain of PAR2 from the cell surface without triggering receptor endocytosis as trypsin does. Cleavage does not activate PAR2, but disarms the recptor for subsequent activation by trypsin | ? | |
proteinase-activated receptor 2 + H2O | the enzyme cleaves proteinase-activated receptor 2 to remove the extracellular Flag epitope | Pseudomonas aeruginosa | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
elastolytic metalloproteinase | - |
Pseudomonas aeruginosa |
EPa | - |
Pseudomonas aeruginosa |
Pseudomonas aeruginosa elastase | - |
Pseudomonas aeruginosa |