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Literature summary for 3.4.24.25 extracted from

  • Benitez, J.A.; Silva, A.J.
    Vibrio cholerae hemagglutinin(HA)/protease An extracellular metalloprotease with multiple pathogenic activities (2016), Toxicon, 115, 55-62 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.25

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular secretion of HA/protease into the extracellular medium is a two stage process. First, the preproprotein or primary translation product is translocated through the cytoplasmic membrane with removal of its signal peptide by a Sec-dependent mechanism. Second, the proprotein folds in the periplasmic space and is secreted across the outer membrane via the type II secretion system, a multiprotein complex encoded by 12 eps (extracellular protein secretion) genes Vibrio cholerae
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Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ Zn2+-dependent metalloprotease Vibrio cholerae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
HlyA protein + H2O Vibrio cholerae the enzyme degrades HlyA to diminish Vibrio cholerae hemolytic activity ?
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 ?

Organism

Organism UniProt Comment Textmining
Vibrio cholerae
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 serogroup O1 and O139, non-O1/O139 strains and other pathogenic vibrios
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification secretion of HA/protease into the extracellular medium is a two stage process. First, the preproprotein or primary translation product is translocated through the cytoplasmic membrane with removal of its signal peptide by a Sec-dependent mechanism. Second, the proprotein folds in the periplasmic space and is secreted across the outer membrane via the type II secretion system, a multiprotein complex encoded by 12 eps (extracellular protein secretion) genes. Removal of the HA/protease propeptide and C-terminal processing is presumed to occur in the extracellular medium through an autocatalytic mechanism Vibrio cholerae

Source Tissue

Source Tissue Comment Organism Textmining
culture fluid secretion of HA/protease into the extracellular medium is a two stage process. First, the preproprotein or primary translation product is translocated through the cytoplasmic membrane with removal of its signal peptide by a Sec-dependent mechanism. Second, the proprotein folds in the periplasmic space and is secreted across the outer membrane via the type II secretion system, a multiprotein complex encoded by 12 eps (extracellular protein secretion) genes Vibrio cholerae
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
HlyA protein + H2O the enzyme degrades HlyA to diminish Vibrio cholerae hemolytic activity Vibrio cholerae ?
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 ?

Synonyms

Synonyms Comment Organism
HA/protease
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 Vibrio cholerae
hAPA
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 Vibrio cholerae

General Information

General Information Comment Organism
physiological function the enzyme exhibits a broad range of potentially pathogenic activities in cell culture and animal models. The activities include the covalent modification of other toxins, the degradation of the protective mucus barrier and disruption of intestinal tight junctions Vibrio cholerae