Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | involvement of MT1MMP and TIMP-2 in MMP-2 activation during progression of endometriosis, overview | Homo sapiens | |
prostaglandin E2 | PGE2, significantly increases MMP-2 activity as well as tube formation in endothelial cells. The PGE2-mediated elevation of MMP-2 activity is associated with the pro-angiogenic responses | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required for activity | Homo sapiens | |
Zn2+ | zinc metalloprotease | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P08253 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial cell | - |
Homo sapiens | - |
uterine endometrium | eutopic, and ectopic, ovarian | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloproteinase-2 | - |
Homo sapiens |
MMP-2 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | women with endometriosis show decreased MMP-2 activity in eutopic endometrium as compared to women without endometriosis, while ectopic ovarian endometrioma show significantly elevated MMP-2 activity with disease severity. Increased MMP-2 activation with disease progression | Homo sapiens |
physiological function | regulation of matrix metalloproteinase-2 activity by COX-2-PGE2-pAKT axis promotes angiogenesis in endometriosis. Analysis of the regulation of MMP-2 activity in endothelial cells and on angiogenesis during progression of ovarian endometriosis, overview. Involvement of MT1MMP and TIMP-2 in MMP-2 activation during progression of endometriosis | Homo sapiens |