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Literature summary for 3.4.24.24 extracted from
- Activity of matrix metalloproteinase 2 and 9 isoforms in sputum samples from individuals infected with M. tuberculosis (2019), Microb. Pathog., 135, 103607 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | the enzyme is secreted | Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | a zinc-dependent metalloprotease | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gelatin + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P08253 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| sputum | Mycobacterium tuberculosis stimulates matrix metalloproteinases secretion in the host. Analysis of the patterns of matrix metalloproteinase 9 (MMP-9) and 2 (MMP-2) isoforms in sputum samples, overview | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gelatin + H2O | - |
Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | MMP-2 has two isoforms: the 72 kDa latent form and an active form of 62 kDa, which is generated from the 10 kDa pro-domain cut-off. MMP-2 isoforms identification and determination of activities, overview | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Matrix metalloproteinase 2 | - |
Homo sapiens |
| MMP-2 | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | Mycobacterium tuberculosis stimulates matrix metalloproteinases secretion in the host | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| additional information | MMP-2 has two isoforms: the 72 kDa latent form and an active form of 62 kDa, which is generated from the 10 kDa pro-domain cut-off. MMP-2 isoforms identification and determination of activities, overview | Homo sapiens |
| physiological function | MMP-2 isoforms do not seem to be directly involved with Mycobacterium tuberculosis evolution of infection | Homo sapiens |
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Release 2023.1 (January 2023)
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