Cloned (Comment) | Organism |
---|---|
gene MMP2, genotyping in Tunesian population. The levels of MMP-2 mRNA expression in patients containing the CC genotype are much higher compared with cells with the CT genotype. The frequency of the MMP-2 CC genotype is significantly higher in colorectal cancer patients when compared with controls | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required for activity | Homo sapiens | |
Zn2+ | zinc metalloprotease | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P08253 | Tunesian population | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colorectal cancer cell | higher intensity of staining of MMP-2 is observed in regions of invasion of the muscularis mucosa compared with superficial portions of the tumor in colorectal cancer | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
gelatinase A | - |
Homo sapiens |
matrix metalloproteinase-2 | - |
Homo sapiens |
MMP-2 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | significant progressive increase in total MMP-2 plasma levels with progression from adenomatous polyps through advancing Dukes stages | up |
General Information | Comment | Organism |
---|---|---|
physiological function | matrix metalloproteinase-2 (gelatinase A) is a mediator of cancer metastasis, but it is also thought to be involved in several aspects of cancer development, including cell growth and inflammation. MMP-2 may be associated with colorectal cancer development and invasion in the Tunisian population | Homo sapiens |