Activating Compound | Comment | Organism | Structure |
---|---|---|---|
heparan sulfate | essential for thrombin-mediated activation of pro-MMP-2 | Homo sapiens | |
syndecan-1 | expression of syndecan-1 increases thrombin-mediated activation of pro-MMP-2 in K562 cells | Homo sapiens | |
thrombin | dependent on, molecular mechanisms underlying thrombin-mediated MMP-2 activation, overview. Interaction of MMP-2 with exosites 1 and 2 of thrombin is crucial for thrombin- mediated MMP-2 degradation, and inhibition of this interaction by heparan sulfate or hirudin fragment results in a decrease in MMP-2 degradation, interaction between exosite 1 and hemopexin-like domain of MMP-2 | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of His- and myc-tagged pro-MMP-2 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | simultaneous binding of each ligand heparan sulfate and hirudin to the exosites is necessary for the complete inhibition of MMP-2 degradation by thrombin | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | dependent on | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
K-562 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloprotease 2 | - |
Homo sapiens |
MMP-2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | thrombin-dependent MMP-2 activity is regulated by heparan sulfate, molecular mechanism, regulatory role of hemopexin-like domain in MMP-2 degradation, overview | Homo sapiens |