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Literature summary for 3.4.24.24 extracted from

  • Rutges, J.; Kummer, J.; Oner, F.; Verbout, A.; Castelein, R.; Roestenburg, H.; Dhert, W.; Creemers, L.
    Increased MMP-2 activity during intervertebral disc degeneration is correlated to MMP-14 levels (2008), J. Pathol., 214, 523-530.
    View publication on PubMed
Search for more literature for 3.4.24.24

Activating Compound

Activating Compound Comment Organism Structure
MMP-14 MMP-14 activates MMP-2 during degeneration of invertebral disc, a major activation pathway of MMP-2 involves complex formation with MMP-14 and a tissue inhibitor of metalloproteinases-2, TIMP-2, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
tissue inhibitor of metalloproteinases-2 TIMP-2, complex formation with MMP-14 and MMP-2 activates the enzyme, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol main localization in invertebral disc, immunohistochemic analysis, overview Homo sapiens 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
68000
-
 x * 68000, active MMP-2, SDS-PAGE, x * 72000, proMMP-2, SDS-PAGE Homo sapiens
72000
-
 x * 68000, active MMP-2, SDS-PAGE, x * 72000, proMMP-2, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Gelatin + H2O Homo sapiens
-
 ?
-
 ?
additional information Homo sapiens intervertebral disc degeneration is associated with the increased expression of several matrix metalloproteinases, in particular MMP-2, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
annulus fibrosus low content Homo sapiens
-
annulus fibrosus endplate Homo sapiens
-
intervertebral disc
-
 Homo sapiens
-
nucleus pulposus
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O
-
 Homo sapiens ?
-
 ?
Gelatin + H2O gelatin zymography Homo sapiens ?
-
 ?
additional information intervertebral disc degeneration is associated with the increased expression of several matrix metalloproteinases, in particular MMP-2, overview Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 68000, active MMP-2, SDS-PAGE, x * 72000, proMMP-2, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
MMP-2
-
 Homo sapiens