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Literature summary for 3.4.24.24 extracted from

  • Mazzoni, A.; Mannello, F.; Tay, F.R.; Tonti, G.A.; Papa, S.; Mazzotti, G.; Di Lenarda, R.; Pashley, D.H.; Breschi, L.
    Zymographic analysis and characterization of MMP-2 and -9 forms in human sound dentin (2007), J. Dent. Res., 86, 436-440.
    View publication on PubMed
Search for more literature for 3.4.24.24

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
 Homo sapiens
EDTA
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Homo sapiens
Zn2+ dependent on Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
72000
-
 x * 72000, proMMP-2, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Gelatin + H2O Homo sapiens
-
 ?
-
 ?
additional information Homo sapiens activation of MMP-2 may contribute to dentin matrix degradation, which occurs during caries progression and follows rresin bonding. Inhibition of MMP-2 proteolytic activity may slow caries progression and increase the durability of resin-dentin bond, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native MMP-2 from dentin inculding serial dilutions, method development Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
dentin demineralized dentin matrix, extraction is best at acidic conditions of pH 2-3 compared to pH 7.4-EDTA-containing extracts Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O
-
 Homo sapiens ?
-
 ?
Gelatin + H2O gelatin zymography Homo sapiens ?
-
 ?
additional information activation of MMP-2 may contribute to dentin matrix degradation, which occurs during caries progression and follows rresin bonding. Inhibition of MMP-2 proteolytic activity may slow caries progression and increase the durability of resin-dentin bond, overview Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 72000, proMMP-2, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
MMP-2
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens