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Literature summary for 3.4.24.24 extracted from
- Activity of matrix metalloproteinase-2 and -9 and contents of their tissue inhibitors in uterine leiomyoma and corresponding myometrium (2007), Gynecol. Endocrinol., 23, 541-546.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| TIMP-2 | specific for MMP-2 | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | extracellular matrix | Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Homo sapiens |  |
| Zn2+ | - |
Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 62000 | - |
x * 72000, latent MMP-2, SDS-PAGE, x * 62000, activ MMP-2, SDS-PAGE | Homo sapiens |
| 72000 | - |
x * 72000, latent MMP-2, SDS-PAGE, x * 62000, activ MMP-2, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| collagen type IV + H2O | Homo sapiens | - |
? | - |
? | |
| Gelatin + H2O | Homo sapiens | - |
? | - |
? | |
| additional information | Homo sapiens | the enzyme degrades proteins of the extracellular matrix in the uterus and might be involved in the growth of leiomyoma and corresponding myometrium, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
MMP-2 is a constitutive enzyme | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| endometrium | - |
Homo sapiens | - |
| myometrium | derived from premenopausal women aged 45-55 years who underwent total abdominal hysterectomy | Homo sapiens | - |
| uterine leiomyoma cell | fibroids of different size show equal MMP-2 activity | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
enzyme activity in leiomyoma and myometrium, overview | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| collagen type IV + H2O | - |
Homo sapiens | ? | - |
? | |
| Gelatin + H2O | - |
Homo sapiens | ? | - |
? | |
| Gelatin + H2O | gelatin zymography using porcine gelatin type A | Homo sapiens | ? | - |
? | |
| additional information | the enzyme degrades proteins of the extracellular matrix in the uterus and might be involved in the growth of leiomyoma and corresponding myometrium, overview | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 72000, latent MMP-2, SDS-PAGE, x * 62000, activ MMP-2, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| matrix metalloproteinase-2 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.6 | - |
assay at | Homo sapiens |
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