Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | implantation of 9L glioma cells into brain increases the expression of MMP-2, overview | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | - |
Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Rattus norvegicus | |
Zn2+ | - |
Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
66000 | - |
x * 72000, pro-MMP-2, SDS-PAGE, x * 66000, activated MMP-2, SDS-PAGE | Rattus norvegicus |
72000 | - |
x * 72000, pro-MMP-2, SDS-PAGE, x * 66000, activated MMP-2, SDS-PAGE | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | Rattus norvegicus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Fisher344 rats | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | activation | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | expression analysis in brain after implantation of 9L glioma cells, overview | Rattus norvegicus | - |
glioma cell | high expression level of MMP-2 increasing during growth | Rattus norvegicus | - |
additional information | MMP-2 is increased in tumor cells | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | - |
Rattus norvegicus | ? | - |
? | |
Gelatin + H2O | gelatin zymography | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 72000, pro-MMP-2, SDS-PAGE, x * 66000, activated MMP-2, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloproteinase-2 | - |
Rattus norvegicus |
MMP-2 | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Rattus norvegicus |