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Literature summary for 3.4.24.24 extracted from

  • Xu, X.; Wang, Y.; Lauer-Fields, J.L.; Fields, G.B.; Steffensen, B.
    Contributions of the MMP-2 collagen binding domain to gelatin cleavage. Substrate binding via the collagen binding domain is required for hydrolysis of gelatin but not short peptides (2004), Matrix Biol., 23, 171-181.
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
additional information recombinant collagen binding domain of enzyme, competitive inhibition of gelatin binding to intact enzyme by 73%, inhibition of enzyme-dependent cleavage of an 11 amino acid short protein fragment by less than 10% Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
dimethyl sulfoxide presence of 2% dimethyl sulfoxide disrupts interactions of enzyme with substrate and thereby reduces activity by 70% Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens collagen binding domain is absolutely required for enzyme-dependent cleavage of full-length collagen alpha-chain, but not for short protein fragments such as those generated by hydrolysis of gelatin ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 recombinant enzyme
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7-methylcoumaryl-L-Pro-L-Lys-L-Gln-L-Gln-L-Phe-L-Phe-Gly-L-Leu-L-Lys-(2,4-dinitrophenyl)-Gly + H2O
-
 Homo sapiens ?
-
 ?
Gelatin + H2O
-
 Homo sapiens ?
-
 ?
additional information collagen binding domain is absolutely required for enzyme-dependent cleavage of full-length collagen alpha-chain, but not for short protein fragments such as those generated by hydrolysis of gelatin Homo sapiens ?
-
 ?