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Literature summary for 3.4.24.23 extracted from

  • Xiao, Z.; Chen, C.; Meng, T.; Zhang, W.; Zhou, Q.
    Resveratrol attenuates renal injury and fibrosis by inhibiting transforming growth factor-beta pathway on matrix metalloproteinase 7 (2016), Exp. Biol. Med. (Maywood), 241, 140-146 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene MMP7, quantitative real-time PCR enzyme expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information shRNA interfering MMP7 downregulates MMP Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ a zinc metalloproteinase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P09237
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium
-
 Homo sapiens
-
HK-2 cell
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
mesenchyme
-
 Homo sapiens
-
renal tubule epithelium
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase 7
-
 Homo sapiens
MMP7
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens resveratrol inhibits MMP7 expression down

General Information

General Information Comment Organism
malfunction resveratrol attenuates renal injury and fibrosis by inhibiting epithelial-mesenchymal transition (EMT) process which is attributed to the fact that the up-regulated shRNA interfering MMP7 and sirtuin 1 (SIRT1) by resveratrol deacetylates Smad4 and inhibits MMP7 expression. In developing renal fibrosis, tubular epithelial cells in the kidney undergo epithelial-mesenchymal transition (EMT). Resveratrol reverses human kidney 2 (HK-2) cell EMT, renal I/R injury, and renal fibrosis. MMP7 inhibition is responsible for RSV-induced EMT repression Homo sapiens
physiological function matrix metalloproteinase 7 (MMP7) is reported to reduce E-cadherin and induce EMT by upregulation of beta-catenin/lymphoid enhancer-binding factor 1 (LEF1) signaling Homo sapiens