Application | Comment | Organism |
---|---|---|
diagnostics | matrix metalloproteinase 7 is a useful marker for 5-fluorouracil-based adjuvant chemotherapy in stage II and stage III colorectal cancer patients | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | the enzyme is expressed in the cytoplasm in colorectal cancer cells | Homo sapiens | 5737 | - |
extracellular | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | a zinc metalloprotease | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09237 | gene MMP7 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon cancer cell | MMP7 is secreted mainly by tumor cells instead of matrix cells in colorectal cancer | Homo sapiens | - |
colorectal cancer cell | MMP7 is secreted mainly by tumor cells instead of matrix cells in colorectal cancer | Homo sapiens | - |
SW-620 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Matrix metalloproteinase 7 | - |
Homo sapiens |
MMP7 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme is a member of a zinc-dependent endopeptidases family (MMPs) | Homo sapiens |
physiological function | the enzyme plays an important role in tumor microenvironment, it decreases the susceptibility to 5-fluorouracil in colon cancer cells | Homo sapiens |