Protein Variants | Comment | Organism |
---|---|---|
additional information | overexpression of MMP-7, and knocked-down using small inhibitory RNAs | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GM6001 | a broad-spectrum MMP inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
syndecan-2 + H2O | Homo sapiens | MMP-7 cleaves the N-terminal Leu149 residue in the extracellular domain of syndecan-2 to a product of about 45 kDa, MALDI-TOF MS analysis, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colonic cancer cell | - |
Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
HT-29 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
syndecan-2 + H2O | MMP-7 cleaves the N-terminal Leu149 residue in the extracellular domain of syndecan-2 to a product of about 45 kDa, MALDI-TOF MS analysis, overview | Homo sapiens | ? | - |
? | |
syndecan-2 + H2O | MMP-7 cleaves both recombinant syndecan-2 and an endogenously glycosylated syndecan-2 ectodomain in the N-terminus at Leu149 residue in vitro. MMP-7 cleaves the N-terminal Leu residue in the extracellular domain of syndecan-2 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Matrix metalloproteinase-7 | - |
Homo sapiens |
MMP-7 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | overexpression of MMP-7 enhances syndecan-2 shedding, whereas the opposite is true when MMP-7 levels are knocked-down using small inhibitory RNAs | Homo sapiens |
physiological function | the cell surface heparan sulfate proteoglycan syndecan-2 regulates the activation of matrix metalloproteinase-7 as a docking receptor. MMP-7 directly mediates shedding of syndecan-2 from colon cancer cells | Homo sapiens |