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Literature summary for 3.4.24.23 extracted from

  • Choi, S.; Kim, J.Y.; Park, J.H.; Lee, S.T.; Han, I.O.; Oh, E.S.
    The matrix metalloproteinase-7 regulates the extracellular shedding of syndecan-2 from colon cancer cells (2012), Biochem. Biophys. Res. Commun., 417, 1260-1264.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information overexpression of MMP-7, and knocked-down using small inhibitory RNAs Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
GM6001 a broad-spectrum MMP inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
syndecan-2 + H2O Homo sapiens MMP-7 cleaves the N-terminal Leu149 residue in the extracellular domain of syndecan-2 to a product of about 45 kDa, MALDI-TOF MS analysis, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colonic cancer cell
-
Homo sapiens
-
HCT-116 cell
-
Homo sapiens
-
HT-29 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
syndecan-2 + H2O MMP-7 cleaves the N-terminal Leu149 residue in the extracellular domain of syndecan-2 to a product of about 45 kDa, MALDI-TOF MS analysis, overview Homo sapiens ?
-
?
syndecan-2 + H2O MMP-7 cleaves both recombinant syndecan-2 and an endogenously glycosylated syndecan-2 ectodomain in the N-terminus at Leu149 residue in vitro. MMP-7 cleaves the N-terminal Leu residue in the extracellular domain of syndecan-2 Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase-7
-
Homo sapiens
MMP-7
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens

General Information

General Information Comment Organism
malfunction overexpression of MMP-7 enhances syndecan-2 shedding, whereas the opposite is true when MMP-7 levels are knocked-down using small inhibitory RNAs Homo sapiens
physiological function the cell surface heparan sulfate proteoglycan syndecan-2 regulates the activation of matrix metalloproteinase-7 as a docking receptor. MMP-7 directly mediates shedding of syndecan-2 from colon cancer cells Homo sapiens