Inhibitors | Comment | Organism | Structure |
---|---|---|---|
TIMP-1 | from gingival and dermal fibroblasts forms complexes with MMP-7 and inhibits its expression and activity | Oryctolagus cuniculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | MMP-7 is secreted from fibroblasts | Oryctolagus cuniculus | - |
- |
additional information | TGF-1beta mediates the secretion of MMP-7, but TGF-1beta inhibits MMP-7 expression. The MMP-7 gene has three TGF-beta1 inhibitory element, TIE, sites | Oryctolagus cuniculus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | aortic and adventitial | Oryctolagus cuniculus | - |
additional information | no MMP-7 in gingival fibroblasts isolated and cultured from gingiva. Coculture of aorta fiboblasts with fibroblasts from gingiva lead to inhibition of the secreted MMP-7 and reduction of its level at least in part due to the formation of MMP-7/TIMP-1 complexes, after 21 days MMP-7 is completely inhibited, the effect is less with dermal fibroblasts, overview. siRNA TGF-beta1 inhibits the inhibition efficiency of GF on MMP-7 | Oryctolagus cuniculus | - |
Synonyms | Comment | Organism |
---|---|---|
MMP-7 | - |
Oryctolagus cuniculus |
Organism | Comment | Expression |
---|---|---|
Oryctolagus cuniculus | TIMP-1 from gingival and dermal fibroblasts forms complexes with MMP-7 and inhibits its expression and activity. TGF-1beta mediates the secretion of MMP-7, but TGF-1beta inhibits MMP-7 expression. The MMP-7 gene has three TGF-beta1 inhibitory element, TIE, sites | down |