Literature summary for 3.4.24.23 extracted from

Shi, M.D.; Lin, H.H.; Chiang, T.A.; Tsai, L.Y.; Tsai, S.M.; Lee, Y.C.; Chen, J.H.
Andrographolide could inhibit human colorectal carcinoma Lovo cells migration and invasion via down-regulation of MMP-7 expression (2009), Chem. Biol. Interact., 180, 344-352.

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Application

Application	Comment	Organism
drug development	andrographolide is a chemotherapeutic agent due to its ability of inhibiting tumor cell proliferation and inflammation by e.g. supprressing MMP-7	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
andrographolide	a diterpenoid lactone isolated from a traditional herbal medicine Andrographis paniculata, downregulates MMP-7 in colorectal carcinoma LoVo cells leading to inhibition of cell migration and invasion, overview	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colorectal cancer cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
matrix metalloprotease-7	-	Homo sapiens
MMP-7	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	andrographolide diminishes the activity and the mRNA and protein levels of MMP-7, but not MMP-2 or MMP-9. The downregulation of MMP-7 appears to be via the inactivation of activator protein-1, AP-1, overview	down

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Release 2023.1 (January 2023)