Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | MMP-7 is secreted | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung cancer cell | expression levels of fibulin-5 and MMP-7 are inversely correlated in lung tumors | Homo sapiens | - |
NCI-H1299 cell | - |
Homo sapiens | - |
NCI-H460 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Matrix metalloproteinase-7 | - |
Homo sapiens |
MMP-7 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | fibulin-5 downregulates MMP-7, suppression of fibulin-5, as well as deletion of its RGD motif, induces MMP-7 expression in lung. Suppression of MMP-7 expression by fibulin-5 is mediated by an integrin-binding RGD motif via the extracellular signal-regulated kinase pathway | down |
General Information | Comment | Organism |
---|---|---|
malfunction | epigenetic silencing or knockdown of fibulin-5, a vascular ligand for integrin receptors and a suppressor of lung cancer invasion and metastasis, promotes lung cancer invasion and metastasis by activating MMP-7 expression through the ERK pathway, injection of fibulin-5-deficient and unmodified H-460 cells into nude mice, overview | Homo sapiens |