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Literature summary for 3.4.24.23 extracted from

  • Ulmer, T.A.; Keeler, V.; Andre, S.; Gabius, H.J.; Loh, L.; Laferte, S.
    The tumor-associated antigen 90K/Mac-2-binding protein secreted by human colon carcinoma cells enhances extracellular levels of promatrilysin and is a novel substrate of matrix metalloproteinases-2, -7 (matrilysin) and -9: Implications of proteolytic clea (2010), Biochim. Biophys. Acta, 1800, 336-343.
    View publication on PubMed
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Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
tumor-associated antigen 90K + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification proMMP7 needs to be activated to the mature active MMP7 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
colonic cancer cell
-
 Homo sapiens
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HT-29 cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
tumor-associated antigen 90K + H2O
-
 Homo sapiens ?
-
 ?
tumor-associated antigen 90K + H2O i.e. TAA90K or/Mac-2-binding protein. TAA90K binds to pro- and active MMP7, it also binds to extracellular matrix proteins, and it increases the extracellular level of active MMP7 secreted from HT-29 cancer cells. MMP-7-mediated cleavage of TAA90K does not affect its binding to MMP-7, laminin-1, collagen IV and galectin-3 but reduces its interaction with fibronectin and laminin-10, and lowers the levels of proMMP-7 in the HT-29 medium, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase-7
-
 Homo sapiens