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Literature summary for 3.4.24.23 extracted from

  • Guillen-Ahlers, H.; Buechler, S.A.; Suckow, M.A.; Castellino, F.J.; Ploplis, V.A.
    Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice (2008), Carcinogenesis, 29, 1421-1427.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
pharmacology in sulindac-treated ApcMin/+ mice, a genetic model of human familial adenomatous polyposis, collagen genes, viz. Col1a2, Col5a2, Col6a2, and Col6a3, are upregulated, and matrilysin matrix metalloproteases-7 is downregulated. Mmp7 is found in hot spot areas within the tumors of ApcMin/+ mice treated with the vehicle, but is greatly diminished in those mice treated with sulindac Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information ApcMin/+ Mmp7-/- double-deficient mice demonstrate reciprocal relationships of Mmp7 expression and the levels of the collagens Col1a2, Col5a2, Col6a2, and Col6a3 in vivo Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
sulindac in sulindac-treated ApcMin/+ mice, a genetic model of human familial adenomatous polyposis, collagen genes, viz. Col1a2, Col5a2, Col6a2, and Col6a3, are upregulated, and matrilysin matrix metalloproteases-7 is downregulated. Mmp7 is found in hot spot areas within the tumors of ApcMin/+ mice treated with the vehicle, but is greatly diminished in those mice treated with sulindac Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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