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Literature summary for 3.4.24.23 extracted from

  • Sawey, E.T.; Johnson, J.A.; Crawford, H.C.
    Matrix metalloproteinase 7 controls pancreatic acinar cell transdifferentiation by activating the Notch signaling pathway (2007), Proc. Natl. Acad. Sci. USA, 104, 19327-19332.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.23

Protein Variants

Protein Variants Comment Organism
additional information MMP-7-deficient cells do not show activation of Notch-1, which can be restored by recombinant MMP-7, phenotype, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Notch-1 + H2O Mus musculus MMP-7 interacts with the Notch pathway and is required for Notch activation, which leads to dedifferentiation of acinar cells to the nestin-positive transitional cell and further into duct-like epithelia. Besides being necessary for acinar transdifferentiation, it MMP-7 activity is sufficient to induce the process, overview ?
-
 ?
Notch-1 + H2O Mus musculus C57/BL6J MMP-7 interacts with the Notch pathway and is required for Notch activation, which leads to dedifferentiation of acinar cells to the nestin-positive transitional cell and further into duct-like epithelia. Besides being necessary for acinar transdifferentiation, it MMP-7 activity is sufficient to induce the process, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q10738 C57BL/6J mice
-
Mus musculus C57/BL6J Q10738 C57BL/6J mice
-

Source Tissue

Source Tissue Comment Organism Textmining
lacrimal gland acinar cell
-
 Mus musculus
-
pancreas
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Notch-1 + H2O
-
 Mus musculus ?
-
 ?
Notch-1 + H2O MMP-7 interacts with the Notch pathway and is required for Notch activation, which leads to dedifferentiation of acinar cells to the nestin-positive transitional cell and further into duct-like epithelia. Besides being necessary for acinar transdifferentiation, it MMP-7 activity is sufficient to induce the process, overview Mus musculus ?
-
 ?
Notch-1 + H2O
-
 Mus musculus C57/BL6J ?
-
 ?
Notch-1 + H2O MMP-7 interacts with the Notch pathway and is required for Notch activation, which leads to dedifferentiation of acinar cells to the nestin-positive transitional cell and further into duct-like epithelia. Besides being necessary for acinar transdifferentiation, it MMP-7 activity is sufficient to induce the process, overview Mus musculus C57/BL6J ?
-
 ?

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase 7
-
 Mus musculus
MMP-7
-
 Mus musculus