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Literature summary for 3.4.24.23 extracted from

  • Ichikawa, Y.; Ishikawa, T.; Momiyama, N.; Kamiyama, M.; Sakurada, H.; Matsuyama, R.; Hasegawa, S.; Chishima, T.; Hamaguchi, Y.; Fujii, S.; Saito, S.; Kubota, K.; Hasegawa, S.; Ike, H.; Oki, S.; Shimada, H.
    Matrilysin (MMP-7) degrades VE-cadherin and accelerates accumulation of beta-catenin in the nucleus of human umbilical vein endothelial cells (2006), Oncol. Rep., 15, 311-315.
    View publication on PubMed
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Application

Application Comment Organism
pharmacology MMP-7 is an important target for antimetastasis therapy of colorectal cancer because it is a strong proteolytic factor secreted from the cancer cell itself and it induces tumor angiogenesis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens MMP-7 is a strong proteolytic factor secreted from the cancer cell itself and it induces tumor angiogenesis, MMP-7 plays important roles in colon cancer invasion ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P09237
-
-

Source Tissue

Source Tissue Comment Organism Textmining
carcinoma cell secretion of the enzyme Homo sapiens
-
colonic cancer cell
-
 Homo sapiens
-
umbilical vein endothelial cell expression analysis, overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information MMP-7 is a strong proteolytic factor secreted from the cancer cell itself and it induces tumor angiogenesis, MMP-7 plays important roles in colon cancer invasion Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
MMP-7
-
 Homo sapiens