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Literature summary for 3.4.24.23 extracted from

  • McCaig, C.; Duval, C.; Hemers, E.; Steele, I.; Pritchard, D.M.; Przemeck, S.; Dimaline, R.; Ahmed, S.; Bodger, K.; Kerrigan, D.D.; Wang, T.C.; Dockray, G.J.; Varro, A.
    The role of matrix metalloproteinase-7 in redefining the gastric microenvironment in response to Helicobacter pylori (2006), Gastroenterology, 130, 1754-1763.
    View publication on PubMed
Search for more literature for 3.4.24.23

Activating Compound

Activating Compound Comment Organism Structure
additional information infections with Helicobacter pylori increases MMP-7 expression in the stomach epithelium, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Collagen + H2O Homo sapiens
-
 ?
-
 ?
insulin-like growth factor binding protein-5 + H2O Homo sapiens in the medium of gastric myofibroblasts, knockdown of IGFBP-5 abolished the myofibroblast proliferation response to MMP-7, overview ?
-
 ?
additional information Homo sapiens MMP-7 is involved in signaling between epithelial cells and a key stromal cell type, the myofibroblast, via insulin-like growth factor binding protein-5 cleavage and IGF-II release, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P09237
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium MMP-7 is uniquely produced in epithelia Homo sapiens
-
gastric gland
-
 Homo sapiens
-
myofibroblast primary Homo sapiens
-
stomach
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Collagen + H2O
-
 Homo sapiens ?
-
 ?
insulin-like growth factor binding protein-5 + H2O
-
 Homo sapiens ?
-
 ?
insulin-like growth factor binding protein-5 + H2O in the medium of gastric myofibroblasts, knockdown of IGFBP-5 abolished the myofibroblast proliferation response to MMP-7, overview Homo sapiens ?
-
 ?
additional information MMP-7 is involved in signaling between epithelial cells and a key stromal cell type, the myofibroblast, via insulin-like growth factor binding protein-5 cleavage and IGF-II release, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase-7
-
 Homo sapiens
MMP-7
-
 Homo sapiens