Literature summary for 3.4.24.23 extracted from

Zhang, Z.; Winyard, P.G.; Chidwick, K.; Murphy, G.; Wardell, M.; Carrell, R.W.; Blake, D.R.
Proteolysis of human native and oxidised alpha 1-proteinase inhibitor by matrilysin and stromelysin (1994), Biochim. Biophys. Acta, 1199, 224-228.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	enzyme could play a role in inflammatory tissue damage by proteolytically inactivating alpha1PI	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
alpha1PI + H2O	protein, inhibitor of elastase, inactivation by cleavage of Pro357-Met358 peptide bond of its reactive centre	Homo sapiens	?	-	?
additional information	enzyme could play a role in inflammatory tissue damage by proteolytically inactivating alpha1PI	Homo sapiens	?	-	?
Oxidized alpha1PI + H2O	cleavage of Phe352-Leu353 bond	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)