Literature summary for 3.4.24.22 extracted from

Avouac, J.; Guignabert, C.; Hoffmann-Vold, A.M.; Ruiz, B.; Dorfmuller, P.; Pezet, S.; Amar, O.; Tu, L.; Van Wassenhove, J.; Sadoine, J.; Launay, D.; Elhai, M.; Cauvet, A.; Subramaniam, A.; Resnick, R.; Hachulla, E.; Molberg, Oe.; Kahan, A.; Humbert, M.; Allanore, Y.
Role of stromelysin 2 (matrix metalloproteinase 10) as a novel mediator of vascular remodeling underlying pulmonary hypertension associated with systemic sclerosis (2017), Arthritis Rheumatol., 69, 2209-2221 .

Application

Application	Comment	Organism
diagnostics	diagnostic value of MMP-10 in patients with systemic sclerosis (SSc)-associated pulmonary hypertension (PH)	Homo sapiens
diagnostics	diagnostic value of MMP-10 in patients with systemic sclerosis (SSc)-associated pulmonary hypertension (PH)	Mus musculus

Cloned (Comment)	Organism
MMP-10 real-time PCR quantitative expression analysis	Homo sapiens
MMP-10 real-time PCR quantitative expression analysis	Mus musculus

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	overexpressed MMP10 localizes to the cytoplasm	Homo sapiens	5737	-
cytoplasm	overexpressed MMP10 localizes to the cytoplasm	Mus musculus	5737	-

Metals/Ions	Comment	Organism	Structure
Zn2+	zinc metalloproteinase	Homo sapiens
Zn2+	zinc metalloproteinase	Mus musculus

Organism	UniProt	Comment	Textmining
Homo sapiens	P09238	-	-
Mus musculus	O55123	-	-

Source Tissue	Comment	Organism	Textmining
blood vessel	-	Homo sapiens	-
blood vessel	-	Mus musculus	-
endothelium	-	Homo sapiens	-
endothelium	-	Mus musculus	-
lung	-	Homo sapiens	-
lung	-	Mus musculus	-
additional information	MMP10 is overexpressed in the serum and pulmonary arteries of patients with SSc-associated PH, and its blockade alleviates PH in the Fra-2-Tg mouse model. Immunohistochemic analysis	Homo sapiens	-
additional information	MMP10 is overexpressed in the serum and pulmonary arteries of patients with SSc-associated PH, and its blockade alleviates PH in the Fra-2-Tg mouse model. Immunohistochemic analysis	Mus musculus	-

Organism	Comment	Expression
Homo sapiens	the gene for matrix metalloproteinase 10 is the most significantly upregulated gene in patients with systemic sclerosis (SSc)-associated pulmonary hypertension (PH)	up
Mus musculus	the gene for matrix metalloproteinase 10 is the most significantly upregulated gene in patients with systemic sclerosis (SSc)-associated pulmonary hypertension (PH)	up

General Information	Comment	Organism
malfunction	the gene for matrix metalloproteinase 10 is the most significantly upregulated gene in patients with systemic sclerosis (SSc)-associated pulmonary hypertension (PH). Lack of effect of MMP10 blockade on the development and severity of pulmonary fibrosis but reversal of PH in Fra-2-Tg mice, lung expression patterns. Substantial increase in the levels of MMP10 in the remodeled vessels of Fra-2-Tg mice, efficacy of MMP10 inhibition on the development of PH in Fra-2-Tg mice. MMP10 inhibition acts through the regulation of cell proliferation and apoptosis to alleviate vascular remodeling and the signs of PH	Mus musculus
malfunction	the gene for matrix metalloproteinase 10 is the most significantly upregulated gene in patients with systemic sclerosis (SSc)-associated pulmonary hypertension (PH). MMP10 inhibition acts through the regulation of cell proliferation and apoptosis to alleviate vascular remodeling and the signs of PH	Homo sapiens
additional information	biologic functions and differentially expressed genes identified by microarray analysis in patients with SSc-associated PH as compared to SSc patients without PH and healthy controls, overview	Homo sapiens