Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | O55123 | - |
- |
Mus musculus C57BL/6 | O55123 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bronchioalveolar stem cell | - |
Mus musculus | - |
CMT-167 cell | - |
Mus musculus | - |
lung | - |
Mus musculus | - |
lung cancer cell | enzyme Mmp10 is required for maintenance of a highly tumorigenic, cancer-initiating, metastatic stem-like cell population in lung cancer. Mmp10 and Notch4 expression in primary and metastatic lung tumors | Mus musculus | - |
additional information | strong positive correlation between tumor Mmp10 expression and metastatic behavior in many human tumor types. Oncosphere cultures exhibit Mmp10-dependent tumor-initiating activity in vivo | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
Matrix metalloproteinase-10 | - |
Mus musculus |
MMP10 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | strong positive correlation between tumor Mmp10 expression and metastatic behavior in many human tumor types | additional information |
General Information | Comment | Organism |
---|---|---|
malfunction | RNAi-mediated knockdown of Mmp10 leads to a loss of stem cell marker gene expression and inhibition of oncosphere growth, clonal expansion, and transformed growth in vitro. Enzyme Mmp10-deficient cultures show a severe defect in tumor initiation | Mus musculus |
additional information | strong positive correlation between tumor Mmp10 expression and metastatic behavior in many human tumor types | Mus musculus |
physiological function | role for the enzyme in the maintenance, tumorigenicity, and proliferation of mouse lung cancer stem-like cells, overview | Mus musculus |