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Literature summary for 3.4.24.22 extracted from
- Stromelysin-2 (MMP-10) deficiency does not affect adipose tissue formation in a mouse model of nutritionally induced obesity (2009), Biochem. Biophys. Res. Commun., 389, 378-381.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | stromelysin-2 deficiency does not affect adipose tissue formation in a mouse model of nutritionally induced obesity, no effect on total body weight or on subcutaneous adipose tissue mass of mice kept on a high fat diet for 15 weeks, while or gonadal adipose tissue development is reduced, phenotype, overview. Significantly reduced MMP-3 expression in MMP-10-deficient adipose tissues not affecting blood vessel size | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | MMPs belong to a family of over 20 neutral endopeptidases that are collectively able to cleave all extracellular matrix components as well as many non-extracellular matrix proteins. The stromelysins, MMP-3, MMP-10 and MMP-11, have a domain arrangement similar to that of collagenases, but they do not cleave interstitial collagens | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
male C57BL/6J mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipose tissue | subcutaneous and gonadal adipose tissue | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | MMPs belong to a family of over 20 neutral endopeptidases that are collectively able to cleave all extracellular matrix components as well as many non-extracellular matrix proteins. The stromelysins, MMP-3, MMP-10 and MMP-11, have a domain arrangement similar to that of collagenases, but they do not cleave interstitial collagens | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MMP-10 | - |
Mus musculus |
| stromelysin-2 | - |
Mus musculus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | stromelysin-2 is slightly downregulated in obese adipose tissue compared to non-obese adipose tissue | down |
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