Literature summary for 3.4.24.22 extracted from

Salmela, M.T.; Pender, S.L.; Karjalainen-Lindsberg, M.L.; Puolakkainen, P.; Macdonald, T.T.; Saarialho-Kere, U.
Collagenase-1 (MMP-1), matrilysin-1 (MMP-7), and stromelysin-2 (MMP-10) are expressed by migrating enterocytes during intestinal wound healing (2004), Scand. J. Gastroenterol., 39, 1095-1104.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	enzyme is involved in intestinal re-epithelialization in vivo and up-regulated by cytokines involved in wound repair	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	patients with ischemic colitis	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Caco-2 cell	induction of enzyme expression by TNF-alpha and EGF	Homo sapiens	-
enterocyte	expression of matrix metalloproteinases MMP-1, MMP-7 and MMP-10 by migrating enterocytes bordering intestinal ulcers	Homo sapiens	-
WiDr cell	induction of enzyme expression by TNF-alpha and EGF	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	enzyme is involved in intestinal re-epithelialization in vivo and up-regulated by cytokines involved in wound repair	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)