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Literature summary for 3.4.24.21 extracted from
- A highly conserved, inhibitable astacin metalloprotease from Teladorsagia circumcincta is required for cuticle formation and nematode development (2015), Int. J. Parasitol., 45, 345-355.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene dpy-31, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis | Teladorsagia circumcincta |
| gene dpy-31, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis | Caenorhabditis elegans |
| gene dpy-31, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis | Haemonchus contortus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | complementation of the Caenorhabditis elegans dpy-31(e2770) mutant with the Teladorsagia circumcincta dpy-31 gene | Caenorhabditis elegans |
| additional information | The DPY-31 enzyme from the ovine gastrointestinal nematode Teladorsagia circumcincta mutant strain strain TP224 is able to rescue the defective Caenorhabditis elegans DPY-31 enzyme mutant | Teladorsagia circumcincta |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-[3-(1-aminoethenyl)-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide | - |
Caenorhabditis elegans |  |
| 3-[3-(1-aminoethenyl)-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide | - |
Teladorsagia circumcincta | |
| 6-cyclohexyl-3-[3-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide | - |
Caenorhabditis elegans | |
| 6-cyclohexyl-3-[3-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide | - |
Teladorsagia circumcincta | |
| 6-cyclohexyl-3-[3-[4-(dihydroxymethyl)pyridin-2-yl]-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide | - |
Caenorhabditis elegans | |
| 6-cyclohexyl-3-[3-[4-(dihydroxymethyl)pyridin-2-yl]-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide | - |
Teladorsagia circumcincta | |
| 6-cyclohexyl-N-hydroxy-3-(3-[1-[(methylsulfonyl)amino]ethenyl]-1,2,4-oxadiazol-5-yl)hexanamide | - |
Caenorhabditis elegans | |
| 6-cyclohexyl-N-hydroxy-3-(3-[1-[(methylsulfonyl)amino]ethenyl]-1,2,4-oxadiazol-5-yl)hexanamide | - |
Teladorsagia circumcincta | |
| actinonin | - |
Teladorsagia circumcincta | |
| additional information | compounds with a hydroxamate functional group are potent inhibitors causing body morphology phenotypes consistent with the inhibition of proteases involved in cuticle collagen synthesis | Caenorhabditis elegans | |
| additional information | compounds with a hydroxamate functional group are potent inhibitors causing body morphology phenotypes consistent with the inhibition of proteases involved in cuticle collagen synthesis | Haemonchus contortus | |
| additional information | compounds with a hydroxamate functional group are potent inhibitors causing body morphology phenotypes consistent with the inhibition of proteases involved in cuticle collagen synthesis | Teladorsagia circumcincta |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | a zinc metalloprotease | Teladorsagia circumcincta | |
| Zn2+ | a zinc metalloprotease | Caenorhabditis elegans | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Caenorhabditis elegans | P98060 | gene dpy-31 | - |
| Caenorhabditis elegans N2 | P98060 | gene dpy-31 | - |
| Haemonchus contortus | D5FM33 | gene dpy-31 | - |
| Haemonchus contortus ISE | D5FM33 | gene dpy-31 | - |
| Teladorsagia circumcincta | A0A0C5PRQ1 | an ovine gastrointestinal nematode, gene dpy-31 | - |
| Teladorsagia circumcincta MTci5 | A0A0C5PRQ1 | an ovine gastrointestinal nematode, gene dpy-31 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| larva | - |
Teladorsagia circumcincta | - |
| larva | - |
Caenorhabditis elegans | - |
| larva | - |
Haemonchus contortus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Suc-Ala-Ala-Ala-4-nitroanilide + H2O | - |
Teladorsagia circumcincta | Suc-Ala-Ala-Ala + 4-nitroaniline | - |
? | |
| Suc-Ala-Ala-Ala-4-nitroanilide + H2O | - |
Caenorhabditis elegans | Suc-Ala-Ala-Ala + 4-nitroaniline | - |
? | |
| Suc-Ala-Ala-Ala-4-nitroanilide + H2O | - |
Haemonchus contortus | Suc-Ala-Ala-Ala + 4-nitroaniline | - |
? | |
| Suc-Ala-Ala-Ala-4-nitroanilide + H2O | - |
Haemonchus contortus ISE | Suc-Ala-Ala-Ala + 4-nitroaniline | - |
? | |
| Suc-Ala-Ala-Ala-4-nitroanilide + H2O | - |
Caenorhabditis elegans N2 | Suc-Ala-Ala-Ala + 4-nitroaniline | - |
? | |
| Suc-Ala-Ala-Ala-4-nitroanilide + H2O | - |
Teladorsagia circumcincta MTci5 | Suc-Ala-Ala-Ala + 4-nitroaniline | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| astacin metalloprotease | - |
Teladorsagia circumcincta |
| astacin metalloprotease | - |
Caenorhabditis elegans |
| astacin metalloprotease | - |
Haemonchus contortus |
| DPY-31 | - |
Teladorsagia circumcincta |
| DPY-31 | - |
Caenorhabditis elegans |
| DPY-31 | - |
Haemonchus contortus |
| NAS-35 | - |
Teladorsagia circumcincta |
| NAS-35 | - |
Caenorhabditis elegans |
| NAS-35 | - |
Haemonchus contortus |
| Procollagen C-proteinase | - |
Teladorsagia circumcincta |
| Procollagen C-proteinase | - |
Caenorhabditis elegans |
| Procollagen C-proteinase | - |
Haemonchus contortus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Teladorsagia circumcincta |
| 37 | - |
assay at | Caenorhabditis elegans |
| 37 | - |
assay at | Haemonchus contortus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Teladorsagia circumcincta |
| 8 | - |
assay at | Caenorhabditis elegans |
| 8 | - |
assay at | Haemonchus contortus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | enzyme inhibition causes body morphology phenotypes consistent with the inhibition of proteases involved in cuticle collagen synthesis | Haemonchus contortus |
| malfunction | enzyme inhibition causes body morphology phenotypes consistent with the inhibition of proteases involved in cuticle collagen synthesis. Enzyme mutation causes temperature-sensitive lethality and cuticle defects, a DPY-31 enzyme from the ovine gastrointestinal nematode Teladorsagia circumcincta mutant strain TP224 is able to rescue the Caenorhabditis elegans mutant | Caenorhabditis elegans |
| malfunction | enzyme inhibition causes body morphology phenotypes consistent with the inhibition of proteases involved in cuticle collagen synthesis. The DPY-31 enzyme from the ovine gastrointestinal nematode Teladorsagia circumcincta mutant is able to rescue the defective Caenorhabditis elegans DPY-31 enzyme mutant | Teladorsagia circumcincta |
| additional information | complementation of the Caenorhabditis elegans dpy-31 mutant with the Teladorsagia circumcincta dpy-31 gene | Teladorsagia circumcincta |
| physiological function | the enzyme is a homologue of a vertebrate procollagen C-proteinase and performs a central role in cuticle formation of Caenorhabditis elegans | Caenorhabditis elegans |
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