Literature summary for 3.4.24.21 extracted from

Baska, P.; Wisniewski, M.; Krzyzowska, M.; Dlugosz, E.; Zygner, W.; Gorski, P.; Wedrychowicz, H.
Molecular cloning and characterisation of in vitro immune response against astacin-like metalloprotease Ace-MTP-2 from Ancylostoma ceylanicum (2013), Exp. Parasitol., 133, 472-482.

Search for more literature for 3.4.24.21

Cloned(Commentary)

Cloned (Comment)	Organism
gene Ace-mtp-2, DNA and amino acid seuence determination and analysis, recombinant expression in Escherichia coli strains BL21 and Rosetta and Pichia pastoris strain X33	Ancylostoma ceylanicum

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	the protease has a putative signal peptide and is secreted	Ancylostoma ceylanicum	-	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	zinc metalloprotease	Ancylostoma ceylanicum

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
26700	-	x * 26700, about, sequence calculation	Ancylostoma ceylanicum

Organism

Organism	UniProt	Comment	Textmining
Ancylostoma ceylanicum	Q0Z889	gene Ace-mtp-2	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	the protease has a putative signal peptide, 11 potential phosphorylation sites, and two disulfide bridges revealed by computational analysis	Ancylostoma ceylanicum

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	highest enzyme expression level occurs in the adult stage of the parasite	Ancylostoma ceylanicum	-

Subunits

Subunits	Comment	Organism
?	x * 26700, about, sequence calculation	Ancylostoma ceylanicum

Synonyms

Synonyms	Comment	Organism
Ace-MTP-2	-	Ancylostoma ceylanicum
Ancylostoma ceylanicum metalloprotease 2	-	Ancylostoma ceylanicum
astacin-like metalloprotease	-	Ancylostoma ceylanicum

General Information

General Information	Comment	Organism
additional information	the protease has a putative signal peptide, 11 potential phosphorylation sites, and two disulfide bridges revealed by computational analysis	Ancylostoma ceylanicum
physiological function	the protease is working at the hostparasite interface and is likely be exposed to the hosts immune response. Recombinant Ace-MTP-2 amplifies the in vitro release of TNFalpha and induces release of IFNgamma by lipopolysaccharide activated THP-1 macrophages, overview	Ancylostoma ceylanicum

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)