Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.19 extracted from

  • Lesiak, M.; Augusciak-Duma, A.; Szydlo, A.; Sieron, A.L.
    Blocking angiogenesis with peptides that inhibit the activity of procollagen C-endopeptidase (2009), Pharmacol. Rep., 61, 468-476.
    View publication on PubMed
Search for more literature for 3.4.24.19

Inhibitors

Inhibitors Comment Organism Structure
Cys-Asp-Pro-Ile-Val-Cys inhibits procollagen C-endopeptidase activity in vitro Homo sapiens
Gln-Lys-Arg-Thr-Val-Ile-Cys-Asp-Pro-Ile-Val-Cys-Pro-Pro-Leu-Asn inhibits procollagen C-endopeptidase activity in vitro Homo sapiens
additional information the cyclic form AS1.11c (Gln-Lys-Arg-Thr-Val-Ile-Cys-Asp-Pro-Ile-Val-Cys-Pro-Pro-Leu-Asn) does not inhibit procollagen C-endopeptidase activity on procollagen type I Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Procollagen type I + H2O
-
 Homo sapiens Type I pNcollagen + C-propeptides
-
 ?

Synonyms

Synonyms Comment Organism
BMP-1
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction angiogenesis is inhibited by blocking the activity of procollagen C-endopeptidase Homo sapiens
physiological function BMP-1 is one of two key enzymes crucial for conversion of fibrillar procollagens to self-assembling collagen monomers which plays a crucial role in the formation of new blood vessels, maintenance of their growth, and in the formation of skeletal components during tissue development Homo sapiens