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Literature summary for 3.4.24.18 extracted from
- A meprin inhibitor suppresses atherosclerotic plaque formation in ApoE-/- mice (2009), Atherosclerosis, 207, 84-92.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | meprin inhibition is therapeutically useful in atherosclerosis prevention | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| actinonin | - |
Mus musculus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | meprin inhibition elevates levels of natriuretic peptides in plasma and the vascular wall, decreases plaque volume and suppresses lipid deposition in carotid arteries, reduces production of reactive oxygen species and apoptosis (which are associated with atherosclerosis) in the vascular wall, and increases natriuretic peptide function on cell apoptosis, proliferation, and intracellular reactive oxygen species generation in the THP-1 cell line and primary vascular smooth muscle cells | Mus musculus |
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Release 2023.1 (January 2023)
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