Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.18 extracted from

  • Mathew, R.; Futterweit, S.; Valderrama, E.; Tarectecan, A.A.; Bylander, J.E.; Bond, J.S.; Trachtman, H.
    Meprin-alpha in chronic diabetic nephropathy: interaction with the renin-angiotensin axis (2005), Am. J. Physiol. Renal Physiol., 289, F911-F921.
    View publication on PubMed

Application

Application Comment Organism
medicine animals treated with streptozocin, representing a model of type 1 diabetes mellitus, show inverse relationship between renal enzyme content and the severity of the renal injury Rattus norvegicus
medicine db/db mice lacking the hypothalamic leptin receptor, representing a model of type 2 diabetes mellitus, manifest decreased enzyme and meprin-beta gene and protein expression before the development of overt kidney disease. Inverse relationship between renal enzyme content and the severity of the renal injury. Treatment with an inhibitor of angiotensin-converting enzyme is more effective than ANG II receptor type I blocker therapy in ameliorating diabetic nephrosis Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
db/db mice lacking the hypothalamic leptin receptor, representing a model of type 2 diabetes mellitus
-
Rattus norvegicus
-
treated with streptozocin, representing a model of type 1 diabetes mellitus
-

Synonyms

Synonyms Comment Organism
meprin-alpha
-
Mus musculus
meprin-alpha
-
Rattus norvegicus