Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | grapefruit seed extracts inhibit dentin matrix degradation by the enzyme. A grape seed extract mouthrinse and its active components not only have an anti-MMP action but also modify the dentin surface accessibility. The mouthrinse and its active components appear to limit the disorganization inside dentinal tubules induced by the MMP-3 action | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme degrades several dentin matrix proteins, a demineralized and pretreated dentin block is used for activity assays. Enzyme MMP-3 is capable of degrading the protein core of proteoglycans, resulting in the release of soluble glycosaminoglycans | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P08254 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
dentin | MMP-3 has been identified in predentin and in dentin, where it localizes within the intertubular dentin, along the collagen fibrils | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme degrades several dentin matrix proteins, a demineralized and pretreated dentin block is used for activity assays. Enzyme MMP-3 is capable of degrading the protein core of proteoglycans, resulting in the release of soluble glycosaminoglycans | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MMP-3 | - |
Homo sapiens |
Proteoglycanase | - |
Homo sapiens |
stromelysin-1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme performs dentin matrix degradation | Homo sapiens |