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Literature summary for 3.4.24.17 extracted from

  • Wilfong, E.M.; Du, Y.; Toone, E.J.
    An enthalpic basis of additivity in biphenyl hydroxamic acid ligands for stromelysin-1 (2012), Bioorg. Med. Chem. Lett., 22, 6521-6524.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
additional information drug discovery via thermodynamic additivity, thermodynamic additivity analysis using stromelysin-1 and a series of biphenyl hydroxamate ligands identified through fragment additivity, overview. Additivity arises from enthalpic effects, while interaction entropies are unfavorable, the thermodynamic behavior is masked by proton transfer Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information thermodynamic additivity analysis using stromelysin-1 and a series of biphenyl hydroxamate ligands identified through fragment additivity, thermodynamics determined by isothermal titration calorimetry, corrected for proton transfer events, overview. Additivity arises from enthalpic effects, while interaction entropies are unfavorable, the thermodynamic behavior is masked by proton transfer Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ modeling of stromelysin-1 binding biphenol moiety in the S1' pocket and acetohydroxamic acid chelating catalytic zinc Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P08254
-
-

Synonyms

Synonyms Comment Organism
stromelysin-1
-
Homo sapiens