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Literature summary for 3.4.24.17 extracted from

  • Husslein, H.; Haider, S.; Meinhardt, G.; Prast, J.; Sonderegger, S.; Knoefler, M.
    Expression, regulation and functional characterization of matrix metalloproteinase-3 of human trophoblast (2009), Placenta, 30, 284-291.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
p-aminophenylmercuric acetate i.e. APMA, initiates an MMP-3 autocatalytic mechanism by disturbing the interaction of zinc with a critical cysteine residue Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular active MMP-3 is secreted Homo sapiens
-
-
additional information invasive trophoblast cell models secrete bioactive MMP-3 Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ dependent on Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification pro-MMP-3 autoactivates to mature MMP-3, initiated by p-aminophenylmercuric acetate Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast decidual Homo sapiens
-
additional information comparison of basal and interleukin-1beta-dependent MMP-3 expression in SGHPL-4 cells and decidual fibroblasts, overview Homo sapiens
-
placenta distribution and activity of MMP-3 in placenta, overview Homo sapiens
-
SGHPL-4 cell trophoblatsic cell line Homo sapiens
-
trophoblast pro- and active form of MMP-3 are predominantly expressed in purified first trimester villous trophoblasts, in invasive cytotrophoblasts of differentiating explant cultures and in trophoblastic SGHPL-4 cells. Reduced MMP-3 expression in invasive trophoblasts of patients with severe preeclampsia Homo sapiens
-

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-3
-
Homo sapiens
MMP-3
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens reduced MMP-3 expression in invasive trophoblasts of patients with severe preeclampsia down
Homo sapiens MMP-3 is induced by interleukin-1beta, which, despite its effects on MMP-3 expression, fails to significantly alter invasion of SGHPL-4 cells through Matrigel-coated transwells up

General Information

General Information Comment Organism
malfunction reduced MMP-3 expression in invasive trophoblasts of patients with severe preeclampsia Homo sapiens
physiological function in addition to the decidua, MMP-3 of trophoblasts may contribute to the regulation of the IGF system by degrading IGFBP-1 Homo sapiens