Activating Compound | Comment | Organism | Structure |
---|---|---|---|
p-aminophenylmercuric acetate | i.e. APMA, initiates an MMP-3 autocatalytic mechanism by disturbing the interaction of zinc with a critical cysteine residue | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | active MMP-3 is secreted | Homo sapiens | - |
- |
additional information | invasive trophoblast cell models secrete bioactive MMP-3 | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | dependent on | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | pro-MMP-3 autoactivates to mature MMP-3, initiated by p-aminophenylmercuric acetate | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | decidual | Homo sapiens | - |
additional information | comparison of basal and interleukin-1beta-dependent MMP-3 expression in SGHPL-4 cells and decidual fibroblasts, overview | Homo sapiens | - |
placenta | distribution and activity of MMP-3 in placenta, overview | Homo sapiens | - |
SGHPL-4 cell | trophoblatsic cell line | Homo sapiens | - |
trophoblast | pro- and active form of MMP-3 are predominantly expressed in purified first trimester villous trophoblasts, in invasive cytotrophoblasts of differentiating explant cultures and in trophoblastic SGHPL-4 cells. Reduced MMP-3 expression in invasive trophoblasts of patients with severe preeclampsia | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloproteinase-3 | - |
Homo sapiens |
MMP-3 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | reduced MMP-3 expression in invasive trophoblasts of patients with severe preeclampsia | down |
Homo sapiens | MMP-3 is induced by interleukin-1beta, which, despite its effects on MMP-3 expression, fails to significantly alter invasion of SGHPL-4 cells through Matrigel-coated transwells | up |
General Information | Comment | Organism |
---|---|---|
malfunction | reduced MMP-3 expression in invasive trophoblasts of patients with severe preeclampsia | Homo sapiens |
physiological function | in addition to the decidua, MMP-3 of trophoblasts may contribute to the regulation of the IGF system by degrading IGFBP-1 | Homo sapiens |