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Literature summary for 3.4.24.17 extracted from
- Isolation and characterization of human monoclonal antibodies specific to MMP-1A, MMP-2 and MMP-3 (2010), Exp. Cell Res., 316, 836-847.
Application
| Application | Comment | Organism |
|---|---|---|
| analysis | generation of specific recombinant human monoclonal antibody SP3, which may serve as building block for the development of antibody-based therapy strategies in mouse models of pathology | Mus musculus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| recombinant expression of His-tagged isolated MMP-3 catalytic domain as soluble cytoplasmic protein in Escherichia coli | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | generation of specific recombinant human monoclonal antibody SP3, which is specific to the murine MMP-3 catalytic domain | Mus musculus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Mus musculus |  |
| Zn2+ | a zinc-containing endopeptidase | Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
Sv129 mice | - |
| Mus musculus Sv129 | - |
Sv129 mice | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant His-tagged isolated MMP-3 catalytic domain by nickel affinity chromatography from Escherichia coli | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | MMP-3 is strongly expressed in tumor and arthritis specimens, expression patterns of MMP-3 in a variety of healthy, cancerous and arthritic murine tissues, overview | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 + H2O | fluorogenic substrate | Mus musculus | ? | - |
? | |
| Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 + H2O | fluorogenic substrate | Mus musculus Sv129 | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | MMP-3 comprises a signal peptide and a propeptide, a catalytic domain and a hemopexin-like domain | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Matrix metalloproteinase 3 | - |
Mus musculus |
| MMP-3 | - |
Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
assay at | Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | MMP-3 is strongly expressed in tumor and arthritis specimens | Mus musculus |
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Release 2023.1 (January 2023)
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