Protein Variants | Comment | Organism |
---|---|---|
additional information | MMP-3-/- mice kept on high fat diet show adipocyte hypertrophy in adipose tissues | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | MMPs belong to a family of over 20 neutral endopeptidases that are collectively able to cleave all extracellular matrix components as well as many non-extracellular matrix proteins. The stromelysins, MMP-3, MMP-10 and MMP-11, have a domain arrangement similar to that of collagenases, but they do not cleave interstitial collagens | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
male C57BL/6J mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose tissue | subcutaneous and gonadal adipose tissue. Significantly reduced MMP-3 expression in MMP-10-deficient adipose tissues | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | MMPs belong to a family of over 20 neutral endopeptidases that are collectively able to cleave all extracellular matrix components as well as many non-extracellular matrix proteins. The stromelysins, MMP-3, MMP-10 and MMP-11, have a domain arrangement similar to that of collagenases, but they do not cleave interstitial collagens | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MMP-3 | - |
Mus musculus |
stromelysin-1 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | stromelysin-1 is slightly downregulated in obese adipose tissue compared to non-obese adipose tissue. Expression of MMP-3 mRNA in subcutaneous and gonadal adipose tissue is affected and 3.0-3.7fold reduced by MMP-10 deficiency, but vessel size is not affected | down |