Any feedback?
Literature summary for 3.4.24.17 extracted from
- Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates (1985), J. Biol. Chem., 260, 12367-12376.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Oryctolagus cuniculus |  |
| EDTA | - |
Oryctolagus cuniculus | |
| Specific metalloproteinase inhibitor | isolated from human amniotic fluid | Oryctolagus cuniculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Oryctolagus cuniculus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | metalloproteinase | Oryctolagus cuniculus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| additional information | - |
proenzyme form of 51000 MW is activated during isolation to several forms: 41000 MW form after treatment with trypsin or 4-aminophenylmercuric acetate, active forms of MW 21000-25000 and the activatable form of MW 35000 | Oryctolagus cuniculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| culture medium | synovial fibroblasts | Oryctolagus cuniculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Oryctolagus cuniculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-Proteinase inhibitor + H2O | - |
Oryctolagus cuniculus | 2,4-Dinitrophenyl-Pro-Leu-Gly + Ile-Ala-Gly-Arg-NH2 | - |
? | |
| casein + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| Collagen type IV + H2O | no degradation of type I collagen | Oryctolagus cuniculus | More | - |
? | |
| Collagen type IV + H2O | limited activity | Oryctolagus cuniculus | More | - |
? | |
| Elastin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| Fibronectin + H2O | - |
Oryctolagus cuniculus | Intact fibronectin subunit MW 22000 + a disulfide-bonded COOH-terminal MW 20000 polypeptide | - |
? | |
| Gelatin + H2O | limited activity | Oryctolagus cuniculus | ? | - |
? | |
| Immunoglobulin G2a + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| Laminin + H2O | limited activity | Oryctolagus cuniculus | ? | - |
? | |
| Proteoglycan + H2O | - |
Oryctolagus cuniculus | More | - |
? | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
