Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | exclusively | Mus musculus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
gonadotrophin-releasing hormone + H2O | Mus musculus | - |
? | - |
? | |
gonadotrophin-releasing hormone + H2O | Mus musculus C57/BL6J | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
female C57BL?6J | - |
Mus musculus C57/BL6J | - |
female C57BL?6J | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
hypothalamus | the nuclear thimet oligopeptidase is coexpressed with estrogen receptor alpha in hypothalamic cells, and also in ventrolateral portion of the ventromedial hypothalamic nucleus and the midbrain central grey | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
gonadotrophin-releasing hormone + H2O | - |
Mus musculus | ? | - |
? | |
gonadotrophin-releasing hormone + H2O | - |
Mus musculus C57/BL6J | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
EP24.15 | - |
Mus musculus |
TOP | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
metabolism | TOP is regulated by estradiol in female mice | Mus musculus |
physiological function | TOP is a neuropeptidase involved in the regulation of several physiological functions including reproduction. Among its substrates is gonadotrophin-releasing hormone, an important hypothalamic hormone that regulates the synthesis and release of estradiol and facilitates female sexual behaviour | Mus musculus |