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Literature summary for 3.4.24.15 extracted from

  • Cyr, N.E.; Kua, L.H.; Bruce, L.A.; Chadwick, J.G.; Tetel, M.J.; Wolfson, A.J.
    Nuclear thimet oligopeptidase is coexpressed with oestrogen receptor alpha in hypothalamic cells and regulated by oestradiol in female mice (2010), J. Neuroendocrinol., 22, 936-943.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus exclusively Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
gonadotrophin-releasing hormone + H2O Mus musculus
-
?
-
?
gonadotrophin-releasing hormone + H2O Mus musculus C57/BL6J
-
?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
female C57BL?6J
-
Mus musculus C57/BL6J
-
female C57BL?6J
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
hypothalamus the nuclear thimet oligopeptidase is coexpressed with estrogen receptor alpha in hypothalamic cells, and also in ventrolateral portion of the ventromedial hypothalamic nucleus and the midbrain central grey Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
gonadotrophin-releasing hormone + H2O
-
Mus musculus ?
-
?
gonadotrophin-releasing hormone + H2O
-
Mus musculus C57/BL6J ?
-
?

Synonyms

Synonyms Comment Organism
EP24.15
-
Mus musculus
TOP
-
Mus musculus

General Information

General Information Comment Organism
metabolism TOP is regulated by estradiol in female mice Mus musculus
physiological function TOP is a neuropeptidase involved in the regulation of several physiological functions including reproduction. Among its substrates is gonadotrophin-releasing hormone, an important hypothalamic hormone that regulates the synthesis and release of estradiol and facilitates female sexual behaviour Mus musculus