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Literature summary for 3.4.24.15 extracted from

  • Wu, T.J.; Mani, S.K.; Glucksman, M.J.; Roberts, J.L.
    Stimulation of luteinizing hormone-releasing hormone (LHRH) gene expression in GT1-7 cells by its metabolite, LHRH-(1-5) (2005), Endocrinology, 146, 280-286.
    View publication on PubMed
Search for more literature for 3.4.24.15

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular EP24.15 is secreted Mus musculus
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Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc metalloendopeptidase Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pyroGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly + H2O Mus musculus i.e. luteinizing hormone-releasing hormone or LHRH pyroGlu-His-Trp-Ser-Tyr + Gly-Leu-Arg-Pro-Gly i.e. luteinizing hormone-releasing hormone(1-5) or LHRH-(1-5) ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
brain median eminence and preoptic area in close proximity with LHRH cell bodies Mus musculus
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GT1-7 cell hypothalamic cell line, shows low level secretion of EP24.15 Mus musculus
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hypothalamus
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 Mus musculus
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additional information during embryonic development, EP24.15 is localized in the same neuroanatomical regions as LHRH and LHRH-(1-5) Mus musculus
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neuron LHRH neurons Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyroGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly + H2O i.e. luteinizing hormone-releasing hormone or LHRH Mus musculus pyroGlu-His-Trp-Ser-Tyr + Gly-Leu-Arg-Pro-Gly i.e. luteinizing hormone-releasing hormone(1-5) or LHRH-(1-5) ?

Synonyms

Synonyms Comment Organism
EP24.15
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 Mus musculus

General Information

General Information Comment Organism
physiological function involvement of EP24.15 in the modulation of hypothalamic luteinizing hormone-releasing hormone, LHRH, neuronal function Mus musculus