Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.15 extracted from

  • Berti, D.A.; Morano, C.; Russo, L.C.; Castro, L.M.; Cunha, F.M.; Zhang, X.; Sironi, J.; Klitzke, C.F.; Ferro, E.S.; Fricker, L.D.
    Analysis of intracellular substrates and products of thimet oligopeptidase (EC 3.4.24.15) in human embryonic kidney 293 cells (2009), J. Biol. Chem., 284, 14105-14116.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.15

Cloned(Commentary)

Cloned (Comment) Organism
recombinant enzyme from testis, expression in HEK-293 cell Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
N-(1-(RS)-carboxy-3-phenylpropyl)-Ala-Aib-Tyr-p-aminobenzoate
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ELFADKVPKTAENFR + 2 H2O Rattus norvegicus intracellular peptide identified as a substrate by incubation of HEK-293 cell extract with recombinant enzyme. Peptide is derived from peptidylprolyl isomerase A ELFADKVPKTA + Glu-Asn + Phe-Arg
-
 ?
GFGDLKSPAGLQV + H2O Rattus norvegicus intracellular peptide identified as a substrate by incubation of HEK-293 cell extract with recombinant enzyme. Peptide is derived from eukaryotic translation elongation factor 1beta2 GFGDLK + SPAGLQV
-
 ?
IHSLPPEGKLG Rattus norvegicus intracellular peptide identified as a substrate by incubation of HEK-293 cell extract with recombinant enzyme. Peptide is derived from cytochrome c oxidase subunit VIII IHSLPPE + GKLG
-
 ?
KDIEDVFYKY Rattus norvegicus intracellular peptide identified as a substrate by incubation of HEK-293 cell extract with recombinant enzyme. Peptide is derived from arginine/serine-rich splicing factor 1 KDIEDVF + YKY
-
 ?
additional information Rattus norvegicus identification of intracellular substrates by incubation of HEK-293 cell extract with recombinant enzyme or by overexpression of enzyme in HEK-293 cells. A majority of the potential substrate peptides are 9-11 amino acids in length ?
-
 ?
SAMTEEAAVAIKAMAK + H2O Rattus norvegicus intracellular peptide identified as a substrate by incubation of HEK-293 cell extract with recombinant enzyme. Peptide is derived from eukaryotic translation initiation factor 5A SAMTEEAAVAIK + AMAK
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis recombinant enzyme Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7-methoxycoumarin-4-acetyl-PLGPdK-(2,4-dinitrophenyl) + H2O
-
 Rattus norvegicus ?
-
 ?
ELFADKVPKTAENFR + 2 H2O intracellular peptide identified as a substrate by incubation of HEK-293 cell extract with recombinant enzyme. Peptide is derived from peptidylprolyl isomerase A Rattus norvegicus ELFADKVPKTA + Glu-Asn + Phe-Arg
-
 ?
GFGDLKSPAGLQV + H2O intracellular peptide identified as a substrate by incubation of HEK-293 cell extract with recombinant enzyme. Peptide is derived from eukaryotic translation elongation factor 1beta2 Rattus norvegicus GFGDLK + SPAGLQV
-
 ?
IHSLPPEGKLG intracellular peptide identified as a substrate by incubation of HEK-293 cell extract with recombinant enzyme. Peptide is derived from cytochrome c oxidase subunit VIII Rattus norvegicus IHSLPPE + GKLG
-
 ?
KDIEDVFYKY intracellular peptide identified as a substrate by incubation of HEK-293 cell extract with recombinant enzyme. Peptide is derived from arginine/serine-rich splicing factor 1 Rattus norvegicus KDIEDVF + YKY
-
 ?
additional information identification of intracellular substrates by incubation of HEK-293 cell extract with recombinant enzyme or by overexpression of enzyme in HEK-293 cells. A majority of the potential substrate peptides are 9-11 amino acids in length Rattus norvegicus ?
-
 ?
SAMTEEAAVAIKAMAK + H2O intracellular peptide identified as a substrate by incubation of HEK-293 cell extract with recombinant enzyme. Peptide is derived from eukaryotic translation initiation factor 5A Rattus norvegicus SAMTEEAAVAIK + AMAK
-
 ?