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Literature summary for 3.4.24.15 extracted from

  • Knight, C.G.; Dando, P.M.; Barrett, A.J.
    Thimet oligopeptidase specificity: evidence of preferential cleavage near the C-terminus and product inhibition from kinetic analysis of peptide hydrolysis (1995), Biochem. J., 308, 145-150.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.15

Inhibitors

Inhibitors Comment Organism Structure
Arg-Pro-Pro-Gly-Phe
-
 Homo sapiens
Arg-Pro-Tyr-Ile-Leu
-
 Homo sapiens
Ser-Pro-Phe-Arg
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0135
-
 Gly-Pro-Leu-Gly-Pro-Leu-Gly-Pro-Leu-Gly-Pro-Leu
-
 Homo sapiens
0.0149
-
 Gly-Pro-Leu-Gly-Pro-Leu-Gly-Pro-Leu
-
 Homo sapiens
0.0154
-
 Gly-Pro-Leu-Gly-Pro-Leu-Gly-Pro-Leu-Gly-Pro-Leu-Gly-Pro-Leu
-
 Homo sapiens
0.048
-
 Gly-Pro-Leu-Gly-Pro-Leu
-
 Homo sapiens
0.0732
-
 Gly-Pro-Leu
-
 Homo sapiens
0.38
-
 bradykinin
-
 Homo sapiens
1.64
-
 neurotensin
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(Gly-Pro-Leu)n n = 2, 3, 4 and 5, the peptides are cleaved only at Leu-Gly bonds, activity is most rapid with n = 3 and slowest with n = 5. The cleavage fitts a sequential first-order model Homo sapiens Gly-Pro-Leu
-
 ?
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O
-
 Homo sapiens Arg-Pro-Pro-Gly-Phe + Ser-Pro-Phe-Arg
-
 ?
Gly-Pro-Leu-Gly-Pro-Leu + H2O
-
 Homo sapiens ?
-
 ?
Gly-Pro-Leu-Gly-Pro-Leu-Gly-Pro-Leu + H2O
-
 Homo sapiens ?
-
 ?
Gly-Pro-Leu-Gly-Pro-Leu-Gly-Pro-Leu-Gly-Pro-Leu + H2O
-
 Homo sapiens ?
-
 ?
Gly-Pro-Leu-Gly-Pro-Leu-Gly-Pro-Leu-Gly-Pro-Leu-Gly-Pro-Leu + H2O
-
 Homo sapiens ?
-
 ?
additional information no activity with Gly-Phe-Leu-Gly-Phe-Ile-Gly-Phe-Leu Homo sapiens ?
-
 ?
neurotensin + H2O
-
 Homo sapiens ?
-
 ?
pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu i.e. neurotensin Homo sapiens pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg + Arg-Pro-Tyr-Ile-Leu
-
 ?