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Literature summary for 3.4.24.14 extracted from

  • Bekhouche, M.; Leduc, C.; Dupont, L.; Janssen, L.; Delolme, F.; Vadon-Le Goff, S.; Smargiasso, N.; Baiwir, D.; Mazzucchelli, G.; Zanella-Cleon, I.; Dubail, J.; De Pauw, E.; Nusgens, B.; Hulmes, D.J.; Moali, C.; Colige, A.
    Determination of the substrate repertoire of ADAMTS2, 3, and 14 significantly broadens their functions and identifies extracellular matrix organization and TGF-beta signaling as primary targets (2016), FASEB J., 30, 1741-1756 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene ADAMTS14, recombinant expression in HEK-293 cells Homo sapiens
gene ADAMTS2, recombinant expression in HEK-293 cells Homo sapiens
gene ADAMTS3, recombinant expression in HEK-293 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Homo sapiens
-
-
extracellular matrix
-
Homo sapiens 31012
-

Organism

Organism UniProt Comment Textmining
Homo sapiens O15072
-
-
Homo sapiens O95450
-
-
Homo sapiens Q8WXS8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
Homo sapiens
-
additional information human dermatosparactic skin fibroblasts lack active ADAMTS2 and only express low amounts of ADAMTS3 and 14 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADAM10 + H2O
-
Homo sapiens ?
-
?
ADAMTS1 + H2O
-
Homo sapiens ?
-
?
C3a-R + H2O
-
Homo sapiens ?
-
?
CTGF + H2O
-
Homo sapiens ?
-
?
decorin + H2O
-
Homo sapiens ?
-
?
DKK3 + H2O DKK3 is a highly glycosylated molecule. DKK3 is cleaved at positions 126M-/-V127, 128F-/-S129, and 130E-/-T131. Cleavage of DKK3 with potential implication in testis development Homo sapiens ?
-
?
DKK3 + H2O DKK3 is a highly glycosylated molecule. DKK3 is cleaved at positions 126M-/-V127. ADAMTS2 cleaves DKK3 upstream of the 2 conserved cysteine-rich domains known to be responsible for the inhibition of the Wnt pathway. Cleavage of DKK3 with potential implication in testis development Homo sapiens ?
-
?
Fibronectin + H2O release of the 33 kDa fibronectin fragment Homo sapiens ?
-
?
fibulin-2 + H2O
-
Homo sapiens ?
-
?
fibulin-3 + H2O
-
Homo sapiens ?
-
?
HLA-A + H2O
-
Homo sapiens ?
-
?
IGFBP5 + H2O
-
Homo sapiens ?
-
?
LTBP1 + H2O cleavage of LTBP1 by ADAMTS3 at 315P-/-A316 and 775P-/-A776 positions Homo sapiens ?
-
?
LTBP1 + H2O LTBP1 cleavage by ADAMTS14 at the 36P-/-G37 position Homo sapiens ?
-
?
LTBP2 + H2O
-
Homo sapiens ?
-
?
lysyl oxidase + H2O
-
Homo sapiens ?
-
?
lysyl oxidase homologue 1 + H2O
-
Homo sapiens ?
-
?
additional information analysis of substrate specificity and cleavage site specificity, comparison of ADAMTS2, 3, and 14 isozymes, overview Homo sapiens ?
-
?
additional information analysis of substrate specificity and cleavage site specificity, comparison of ADAMTS2, 3, and 14 isozymes, overview. No activity with LTBP1 Homo sapiens ?
-
?
perlecan + H2O
-
Homo sapiens ?
-
?
POTEJ + H2O
-
Homo sapiens ?
-
?
prosaposin + H2O
-
Homo sapiens ?
-
?
TGF-beta RIII + H2O cleavage of TGF-beta RIII (beta-glycan) by ADAMTS3 between the endoglin-like and the zona pellucida domains at the 383P-/-384 site Homo sapiens ?
-
?
TGF-beta RIII + H2O in the presence of active ADAMTS14, the intact soluble TGF-beta RIII disappears, and a single cleavage product of 50 kDa is observed. No other cleavage product is seen Homo sapiens ?
-
?
TGF-beta RIII + H2O in the presence of active ADAMTS2, the intact soluble TGF-beta RIII disappears, and a single cleavage product of 50 kDa is observed. No other cleavage product is seen Homo sapiens ?
-
?
thrombospondin-1 + H2O
-
Homo sapiens ?
-
?
type I aminoprocollagen + H2O
-
Homo sapiens ?
-
?
type I procollagen + H2O cleavage of collagen alpha-1(I) chain and collagen alpha-2(I) chain Homo sapiens ?
-
?
type II procollagen + H2O cleavage of collagen alpha-1(II) chain Homo sapiens ?
-
?
type III procollagen + H2O cleavage of collagen alpha-1(III) chain Homo sapiens ?
-
?
type III procollagen + H2O cleavage of collagen alpha-1(III) chain, cleavage site: GFAP1218-/-1219YYGD Homo sapiens ?
-
?
type IV procollagen + H2O cleavage of collagen alpha-2(IV) chain Homo sapiens ?
-
?
type IV procollagen + H2O cleavage of collagen alpha-2(VI) chain and collagen alpha-2(VI) chain Homo sapiens ?
-
?
type V procollagen + H2O cleavage of collagen alpha-1(V) chain and alpha-2(V) chain Homo sapiens ?
-
?
type V procollagen + H2O cleavage of collagen alpha-2(V) chain Homo sapiens ?
-
?
type XVIII procollagen + H2O cleavage of collagen alpha-1(XVIII) chain Homo sapiens ?
-
?
versican core protein + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
ADAMTS14
-
Homo sapiens
ADAMTS2
-
Homo sapiens
ADAMTS3
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens