Cloned (Comment) | Organism |
---|---|
gene ADAMTS14, recombinant expression in HEK-293 cells | Homo sapiens |
gene ADAMTS2, recombinant expression in HEK-293 cells | Homo sapiens |
gene ADAMTS3, recombinant expression in HEK-293 cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
extracellular matrix | - |
Homo sapiens | 31012 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15072 | - |
- |
Homo sapiens | O95450 | - |
- |
Homo sapiens | Q8WXS8 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Homo sapiens | - |
additional information | human dermatosparactic skin fibroblasts lack active ADAMTS2 and only express low amounts of ADAMTS3 and 14 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADAM10 + H2O | - |
Homo sapiens | ? | - |
? | |
ADAMTS1 + H2O | - |
Homo sapiens | ? | - |
? | |
C3a-R + H2O | - |
Homo sapiens | ? | - |
? | |
CTGF + H2O | - |
Homo sapiens | ? | - |
? | |
decorin + H2O | - |
Homo sapiens | ? | - |
? | |
DKK3 + H2O | DKK3 is a highly glycosylated molecule. DKK3 is cleaved at positions 126M-/-V127, 128F-/-S129, and 130E-/-T131. Cleavage of DKK3 with potential implication in testis development | Homo sapiens | ? | - |
? | |
DKK3 + H2O | DKK3 is a highly glycosylated molecule. DKK3 is cleaved at positions 126M-/-V127. ADAMTS2 cleaves DKK3 upstream of the 2 conserved cysteine-rich domains known to be responsible for the inhibition of the Wnt pathway. Cleavage of DKK3 with potential implication in testis development | Homo sapiens | ? | - |
? | |
Fibronectin + H2O | release of the 33 kDa fibronectin fragment | Homo sapiens | ? | - |
? | |
fibulin-2 + H2O | - |
Homo sapiens | ? | - |
? | |
fibulin-3 + H2O | - |
Homo sapiens | ? | - |
? | |
HLA-A + H2O | - |
Homo sapiens | ? | - |
? | |
IGFBP5 + H2O | - |
Homo sapiens | ? | - |
? | |
LTBP1 + H2O | cleavage of LTBP1 by ADAMTS3 at 315P-/-A316 and 775P-/-A776 positions | Homo sapiens | ? | - |
? | |
LTBP1 + H2O | LTBP1 cleavage by ADAMTS14 at the 36P-/-G37 position | Homo sapiens | ? | - |
? | |
LTBP2 + H2O | - |
Homo sapiens | ? | - |
? | |
lysyl oxidase + H2O | - |
Homo sapiens | ? | - |
? | |
lysyl oxidase homologue 1 + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | analysis of substrate specificity and cleavage site specificity, comparison of ADAMTS2, 3, and 14 isozymes, overview | Homo sapiens | ? | - |
? | |
additional information | analysis of substrate specificity and cleavage site specificity, comparison of ADAMTS2, 3, and 14 isozymes, overview. No activity with LTBP1 | Homo sapiens | ? | - |
? | |
perlecan + H2O | - |
Homo sapiens | ? | - |
? | |
POTEJ + H2O | - |
Homo sapiens | ? | - |
? | |
prosaposin + H2O | - |
Homo sapiens | ? | - |
? | |
TGF-beta RIII + H2O | cleavage of TGF-beta RIII (beta-glycan) by ADAMTS3 between the endoglin-like and the zona pellucida domains at the 383P-/-384 site | Homo sapiens | ? | - |
? | |
TGF-beta RIII + H2O | in the presence of active ADAMTS14, the intact soluble TGF-beta RIII disappears, and a single cleavage product of 50 kDa is observed. No other cleavage product is seen | Homo sapiens | ? | - |
? | |
TGF-beta RIII + H2O | in the presence of active ADAMTS2, the intact soluble TGF-beta RIII disappears, and a single cleavage product of 50 kDa is observed. No other cleavage product is seen | Homo sapiens | ? | - |
? | |
thrombospondin-1 + H2O | - |
Homo sapiens | ? | - |
? | |
type I aminoprocollagen + H2O | - |
Homo sapiens | ? | - |
? | |
type I procollagen + H2O | cleavage of collagen alpha-1(I) chain and collagen alpha-2(I) chain | Homo sapiens | ? | - |
? | |
type II procollagen + H2O | cleavage of collagen alpha-1(II) chain | Homo sapiens | ? | - |
? | |
type III procollagen + H2O | cleavage of collagen alpha-1(III) chain | Homo sapiens | ? | - |
? | |
type III procollagen + H2O | cleavage of collagen alpha-1(III) chain, cleavage site: GFAP1218-/-1219YYGD | Homo sapiens | ? | - |
? | |
type IV procollagen + H2O | cleavage of collagen alpha-2(IV) chain | Homo sapiens | ? | - |
? | |
type IV procollagen + H2O | cleavage of collagen alpha-2(VI) chain and collagen alpha-2(VI) chain | Homo sapiens | ? | - |
? | |
type V procollagen + H2O | cleavage of collagen alpha-1(V) chain and alpha-2(V) chain | Homo sapiens | ? | - |
? | |
type V procollagen + H2O | cleavage of collagen alpha-2(V) chain | Homo sapiens | ? | - |
? | |
type XVIII procollagen + H2O | cleavage of collagen alpha-1(XVIII) chain | Homo sapiens | ? | - |
? | |
versican core protein + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAMTS14 | - |
Homo sapiens |
ADAMTS2 | - |
Homo sapiens |
ADAMTS3 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |